Advanced analytical chromatography - theory and practice D
7.5 ECTS creditsThe course components are treated in lectures, exercises, mandatory laboratory sessions and reports.
The theoretical part of the course includes advanced studies of the following main components:
- Outline of analytical separation processes from a regulatory perspective
- Advanced modern analytical separation theory
- Different liquid chromatographic variants as reversed-phase chromatography, polar-phase chromatography, hydrophilic interaction chromatography, ion pair chromatography, and chiral separation of optical isomers
- Modern chromatographic matrices such as pH stable phases, semi-porous phases, monoliths
- Different trends in separation processes: Green modern chromatographic techniques, super critical fluid chromatography, miniaturisation and separation at high pressure
- Outline of empirical and mechanical modelling of separation processes
- Validation of chemical analysis methods
- Sample preparation of analysis components/pharmaceuticals from different sampling matrices/preparation forms
- Detection principles based on molecule spectroscopy and mass spectroscopy.
In the laboratory part of the course students apply the theoretical components to a task that they get at the beginning of the course and report on it individually before the laboratory session. The task has a focus on the quality control of pharmaceuticals. Students are expected to plan and author the submitted laboratory compendium independently before the laboratory session. Students present the result of the completed laboratory work orally and in writing. In addition, students carry out and report on a risk assessment with consideration of quality requirements, time limits and the environmental requirements of an industrial pharmaceutical perspective.
The theoretical part of the course includes advanced studies of the following main components:
- Outline of analytical separation processes from a regulatory perspective
- Advanced modern analytical separation theory
- Different liquid chromatographic variants as reversed-phase chromatography, polar-phase chromatography, hydrophilic interaction chromatography, ion pair chromatography, and chiral separation of optical isomers
- Modern chromatographic matrices such as pH stable phases, semi-porous phases, monoliths
- Different trends in separation processes: Green modern chromatographic techniques, super critical fluid chromatography, miniaturisation and separation at high pressure
- Outline of empirical and mechanical modelling of separation processes
- Validation of chemical analysis methods
- Sample preparation of analysis components/pharmaceuticals from different sampling matrices/preparation forms
- Detection principles based on molecule spectroscopy and mass spectroscopy.
In the laboratory part of the course students apply the theoretical components to a task that they get at the beginning of the course and report on it individually before the laboratory session. The task has a focus on the quality control of pharmaceuticals. Students are expected to plan and author the submitted laboratory compendium independently before the laboratory session. Students present the result of the completed laboratory work orally and in writing. In addition, students carry out and report on a risk assessment with consideration of quality requirements, time limits and the environmental requirements of an industrial pharmaceutical perspective.
Progressive specialisation:
A1N (has only first鈥恈ycle course/s as entry requirements)
Education level:
Master's level
Admission requirements
Admission to the Master of Science programme in chemical engineering at 果冻传媒, and at least 90 ECTS credits programme courses completed or attended with at least 75 ECTS cr completed, including analytical chemistry 7.5 ECTS cr, or equivalent.
Selection:
Selection is usually based on your grade point average from upper secondary school or the number of credit points from previous university studies, or both.
This course is included in the following programme
- Master of Science in Chemical Engineering (studied during year 5)